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目的探讨河南食管癌高发区林州居民反流性食管炎(reflux esophagitis,RE)的流行特征,加深对食管癌变机理的了解。方法采用统一RE问卷对河南省食管癌高发区508人进行逐一问卷调查。根据反流性食管炎的症状评分,≥12分为阳性诊断标准。结果RE评分≥12分者28人(6%):女性RE检出率(4%,20/508)明显高于男性(2%,8/508)(P<0.05)。结论女性RE发生率明显高于男性,与食管癌男性明显高于女性的性别分布相反,也明显低于西方国家RE发生率,提示可能RE与食管腺癌关系较与食管鳞癌关系密切。
Objective To investigate the epidemiological characteristics of reflux esophagitis (RE) in Linzhou, a high incidence area of esophageal cancer in Henan Province, and to deepen the understanding of esophageal carcinogenesis. Methods A unified RE questionnaire was used to survey 508 people in high risk area of esophageal cancer in Henan Province. According to reflux esophagitis symptom score, ≥ 12 points are divided into positive diagnostic criteria. Results 28 (6%) women with RE score ≥12 were found to have significantly higher detection rate of RE (4%, 20/508) than men (2%, 8/508) (P <0.05). Conclusions The incidence of RE in women is significantly higher than that in men, which is opposite to the gender distribution in women with esophageal cancer and significantly lower than that in western countries, suggesting that the relationship between RE and esophageal adenocarcinoma is more closely related to esophageal squamous cell carcinoma.