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目的对法罗培南钠片在健康人体中的药代动力学进行研究测定。方法共选取18例健康受试者参与此次研究,并根据随机数字表法分成3个组,每组口服剂量不同,分别为测定1组(150mg)、测定2组(300mg)、测定3组(600mg),使用高效液相色谱法对受试者血浆以及尿液中的法罗培南钠浓度进行测定,并使用相应软件对其药代动力学参数进行计算。结果与结论由检测结果可知,其在人体内符合线性规律。
Objective To study the pharmacokinetics of faropenem sodium tablets in healthy volunteers. Methods A total of 18 healthy volunteers were enrolled in the study. According to the random number table, the patients were divided into three groups, each group having different oral doses. The first group (150mg), the second group (300mg), the third group (600 mg), the concentration of faropenem in plasma and urine of subjects was determined using high-performance liquid chromatography and its pharmacokinetic parameters were calculated using the corresponding software. Results and Conclusion From the test results, it is consistent with the linear law in the human body.