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目的分析基层医院新生儿肺炎克雷伯菌感染的临床特点。方法对本院近3年来118例新生儿肺炎克雷伯菌感染的临床资料作系统性回顾分析。结果 (1)肺炎克雷伯菌感染发病率3.48%,胎龄越小发病率与病死率越高,早产儿发病率明显高于足月儿,差异有统计学意义(P<0.01);(2)近年来发病率有增高趋势;(3)发病主要分布在11月～次年4月,即寒冷季节;(4)与机械通气、各种置管等侵入性操作、消毒隔离不严格、抗生素使用不规范等有关;(5)细菌药敏结果显示对普通常用抗生素耐药性强,可供临床实际选择应用的抗生素较少。结论肺炎克雷伯菌是基层医院新生儿最常见的重要致病菌,发病率逐年增多,耐药性强,治疗困难,病死率高,应加强防控。
Objective To analyze the clinical features of neonatal Klebsiella pneumoniae infection in primary hospitals. Methods The clinical data of 118 cases of Klebsiella pneumoniae infection in our hospital during the past 3 years were retrospectively analyzed. Results (1) The incidence of Klebsiella pneumoniae infection was 3.48%. The lower the gestational age was, the higher the morbidity and mortality were. The incidence of premature infants was significantly higher than that of term infants (P <0.01). ( 2) the morbidity has increased in recent years; (3) the incidence mainly distributed in November to April next year, that is, the cold season; (4) with mechanical ventilation, a variety of catheter and other invasive operations, disinfection and isolation is not strict, Antibiotic use is not standardized and so on; (5) bacterial susceptibility results show that the resistance to commonly used antibiotics is strong, less practical antibiotics for clinical selection. Conclusions Klebsiella pneumoniae is the most common neonatal pathogenic bacteria in grass-roots hospitals. The incidence rate is increasing year by year. The drug resistance is strong, the treatment is difficult and the mortality rate is high. Prevention and control should be strengthened.