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目的探讨尿中γ-谷氨酰基转移酶(GGT)活性检测在泌尿系统疾病鉴别诊断中的临床意义。方法用速率法在日立7600-020全自动生化分析仪上测定肾病组(包括肾小球肾炎、肾病综合症,Ⅰ组)80例、肾盂肾炎组(Ⅱ组)75例、肝胆疾病组70例(Ⅲ组)患者及正常对照组(Ⅳ组)150例尿中的GGT活性。同时做尿常规干化学检测尿蛋白,比较两者之间的关系。结果肾病组尿GGT活性明显高于其他3组(P<0.01),而血清中GGT值与肾盂肾炎组、对照组无差异(P>0.05),与肝胆疾病组差异显著(P<0.01)。肝胆疾病组血清GGT活性明显高于其他3组(P<0.01),而尿液中的GGT活性与肾盂肾炎组、对照组相比无统计学意义(P>0.05)。肾病组GGT阳性数为75例,阳性率为93.7%,肾盂肾炎组GGT阳性数为5例,阳性率为6.2%,肾病组阳性率明显高于肾盂肾炎组。尿液GGT活性高低与尿蛋白含量无相关性。结论测定尿液中GGT的活性对肾脏疾病和肾盂肾炎的鉴别诊断有临床应用价值。
Objective To investigate the clinical significance of urinary γ-glutamyl transferase (GGT) activity in the differential diagnosis of urinary system diseases. Methods 80 cases of nephropathy group (including glomerulonephritis and nephrotic syndrome group Ⅰ), 75 cases of pyelonephritis group (Ⅱ group) and 70 cases of hepatobiliary disease group were determined by the rate method on Hitachi 7600-020 automatic biochemical analyzer. (Group Ⅲ) and normal control group (group Ⅳ) 150 cases of urinary GGT activity. At the same time urine routine dry chemical urine protein, compare the relationship between the two. Results The urinary GGT activity in nephropathy group was significantly higher than that in the other three groups (P <0.01). The serum GGT level was not significantly different from pyelonephritis group and control group (P> 0.05), but significantly different from that in hepatobiliary disease group (P <0.01). Serum GGT activity in hepatobiliary disease group was significantly higher than that in the other three groups (P <0.01). However, GGT activity in urine was not significantly different from pyelonephritis group and control group (P> 0.05). Nephropathy GGT positive number 75 cases, the positive rate was 93.7%, pyelonephritis group GGT positive number 5 cases, the positive rate was 6.2%, nephropathy group was significantly higher than the pyelonephritis group. There was no correlation between urinary GGT activity and urinary protein content. Conclusion The determination of GGT activity in urine has clinical value in the differential diagnosis of renal disease and pyelonephritis.