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目的:研究柴胡与葛根配伍在解热、抗炎等方面的作用。方法:56只雄性SD大鼠,随机分为空白组、模型组、阿司匹林组、柴胡组、葛根组、柴胡葛根3∶2组、柴胡葛根4∶5组共7组,每组8只,除空白组外,其余大鼠采用20%的干酵母悬液10 mL.kg-1大鼠背部皮下注射,建立发热模型。观察柴胡、葛根及其不同配伍比例的各组中药煎剂10 g.kg-1对发热大鼠的体温以及血清中炎性介质白介素-1β(IL-1β)含量、髓过氧化物酶(MPO)活性的影响。结果:柴胡、葛根及其不同配伍比例均具有降低发热大鼠体温和血清中IL-1β,MPO的作用,与模型组比(P<0.05或P<0.01)但配伍应用后作用明显优于单味柴胡或葛根。结论:柴胡与葛根配伍在解热、抗炎等方面具有显著的协同增效作用,发挥解热、抗炎的最佳配伍比例为柴胡葛根4∶5。
Objective: To study the role of Radix Bupleuri and Radix Puerariae in antipyretic and anti-inflammatory effects. Methods: Fifty-six male Sprague Dawley rats were randomly divided into 7 groups: blank group, model group, aspirin group, Bupleurum group, Pueraria group, Chaihugeng group 3: Except for the blank group, the other rats were subcutaneously injected subcutaneously with 10 mL.kg-1 of a 20% dry yeast suspension in the back to establish a fever model. The effects of Radix Bupleuri, Radix Puerariae and its different compatibility ratio groups on the body temperature and the levels of interleukin-1β (IL-1β) in serum of rats with fever were observed at the dose of 10 g.kg-1. The levels of myeloperoxidase MPO) activity. Results: Bupleurum chinense and Pueraria lobata could significantly reduce body temperature and serum IL-1β and MPO in rats with fever compared with the model group (P <0.05 or P <0.01), but the effect of compatibility was better than that of the model group Single Bupleurum or Pueraria. Conclusion: Radix Bupleuri and Radix Puerariae have significant synergistic effects on antipyretic and anti-inflammatory effects. The best ratio of anti-inflammatory and anti-inflammatory is Bupleurum chinense 4: 5.