有机磷杀虫药(organophosphorous insecticides,OPI)中毒主要通过抑制体内胆碱酯酶(cholinesterase,ChE)活性,失去分解乙酰胆碱(acetylcholine,ACh)能力,引起体内生理效应部位ACh大量蓄积,使胆碱能神经持续过度兴奋,表现毒蕈碱样、烟碱样和中枢神经系统等中毒症状和体征。严重者常死于呼吸衰竭。OPI属于有机磷酸酯或硫化磷酸酯类化合物,大都为油状液体,呈淡黄色至棕色,稍有挥发性,有大蒜臭味,难溶于水,不易溶于多种有机溶剂,在酸性环境 Organophosphorous insecticides (OPI) poisoning mainly through the inhibition of cholinesterase (ChE) activity in vivo, loss of ability to break down acetylcholine (ACh), causing a large accumulation of physiological ACh site in vivo, making choline Can continue to be over-excited nerves, performance of muscarinic, nicotinic and central nervous system poisoning symptoms and signs. Severe cases often die of respiratory failure. OPI belongs to organophosphate or phosphorothioate compounds, mostly oily liquid, light yellow to brown, slightly volatile, garlic smell, hardly soluble in water, difficult to dissolve in many organic solvents, in acidic environment