目的:观察芪红脑苏汤治疗对小鼠体外凝血时间、血瘀证大鼠血小板聚集率、凝血因子及血液流变学和体内血栓形成的影响。方法:50只KM小鼠随机分为空白对照组、法华林钠0.5mg/kg剂量组、芪红脑苏汤15.7、31.4、62.8g/kg剂量组,连续灌胃给药7天,观察各组小鼠体外凝血时间的变化。60只SD大鼠随机分为空白对照组、模型对照组、尼莫地平8mg/kg剂量组、芪红脑苏汤7.9、15.7、31.4g/kg剂量组,连续灌胃14天后,皮下注射盐酸肾上腺素联合冰水内游泳复制血瘀证模型,观察芪红脑苏汤对血小板聚集率、凝血功能及血液流变学指标的影响。50只KM小鼠,随机分为空白对照组、尼莫地平16mg/kg剂量组、芪红脑苏汤15.7、31.4、62.8g/kg剂量组,连续灌胃给药7天后,除空白对照组外,各组小鼠尾静脉注射血栓诱导剂,对照组注射等体积生理盐水,观察各组小鼠的偏瘫数,偏瘫的恢复数及死亡数,计算偏瘫率与恢复率。结果:芪红脑苏汤15.7g/kg、62.8g/kg均能延长小鼠凝血时间;芪红脑苏汤7.9g/kg、31.4g/kg均能抑制急性血瘀证模型大鼠血小板聚集,芪红脑苏汤7.9g/kg、15.7、31.4g/kg均能延长PT和APTT,7.9、15.7、31.4g/kg能降低大鼠全血粘度,31.4 g/kg能降低血浆黏度、红细胞压积、纤维蛋白;芪红脑苏汤15.7 g/kg、31.4 g/kg、62.8 g/kg均能降低“胶原蛋白-肾上腺素”混合诱导剂致体内血栓偏瘫小鼠偏瘫率和死亡率。结论:芪红脑苏汤具有活血化瘀作用。 Objective: To observe the effect of Qihongnao decoction on clotting time in vitro, platelet aggregation rate, clotting factor, hemorheology and thrombosis in blood stasis rats. Methods: 50 KM mice were randomly divided into blank control group, Fahrenheimen sodium 0.5mg / kg dose group, Qihongnao Soup 15.7,31.4,62.8g / kg dose group, continuous intragastric administration for 7 days, observed Changes of clotting time in vitro in each group of mice. Sixty Sprague-Dawley rats were randomly divided into blank control group, model control group, nimodipine 8mg / kg dose group, QIHONGYU SUTAI dosage group 7.9,15.7,31.4g / kg. After continuous intragastric administration for 14 days, subcutaneous injection of hydrochloric acid Epinephrine combined with ice water swimming blood stasis replicate model to observe the effect of Qi Hong Na Su Tang on platelet aggregation rate, coagulation function and hemorheological parameters. 50 KM mice were randomly divided into blank control group, nimodipine 16mg / kg dose group, Qihongnao Soup 15.7,31.4,62.8g / kg dose group, after continuous gavage for 7 days, except for the blank control group In addition, the thrombosis inducer was injected through tail vein of mice in each group, and the control group was injected with equal volume of normal saline. The number of hemiplegia, recovery of hemiplegia and death in each group were observed to calculate the hemiparesis rate and recovery rate. Results: Qihongnao Soup 15.7g / kg, 62.8g / kg can prolong the clotting time of mice; Qihongnaosu Tang 7.9g / kg, 31.4g / kg can inhibit platelet aggregation in acute blood stasis model rats , SQT and APTT can be prolonged by 7.9g / kg, 15.7 and 31.4g / kg, respectively. The mean viscosity of whole blood of rats was decreased by 7.9, 15.7 and 31.4g / kg, while the viscosity of plasma could be decreased by 31.4g / The results showed that Qiqi Naoshu Decoction 15.7 g / kg, 31.4 g / kg and 62.8 g / kg could reduce the hemiparesis rate and death rate in mice with thrombosis hemiplegia induced by “collagen-adrenaline” rate. Conclusion: Qihongnaosu Tang has the function of promoting blood circulation and removing blood stasis.