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在食管癌高发区林县,对经食管细胞学诊断的294例重度增生,328例轻度增生和336例正常对照者,结合有关因素进行了11年前瞻性研究。结果表明,轻增组和正常组之间食管癌发病无差异,重增组暴露人年发病率为1178.92/10万,是正常对照组的2.39倍,差异非常显著(X~2=8.92,P<0.01)。无论重增、轻增患者或正常对照人群,凡饮用浅层地下水源、吸烟以及家庭经济收入较低者,其食管癌发病危险性明显增加。提示在积极治疗重度增生同时,宜实施综合性预防措施,改善饮水、生活条件和不良生活习惯等。
In Linxian County, a high-risk area of esophageal cancer, 294 cases of severe hyperplasia, 328 cases of mild hyperplasia, and 336 normal controls diagnosed by transesophageal cytology were studied in combination with relevant factors for 11-year prospective studies. The results showed that there was no difference in the incidence of esophageal cancer between the light-increased group and the normal group. The annual incidence rate of exposed individuals in the re-growth group was 1178.92/100,000, which was 2.39 times that of the normal control group. The difference was very significant (X~2=8.92, P). <0.01). Regardless of re-increasing, light-increasing patients or normal control population, the risk of esophageal cancer increased significantly with shallow groundwater sources, smoking, and low household economic income. It is suggested that in the active treatment of severe hyperplasia, comprehensive preventive measures should be implemented to improve drinking water, living conditions and poor living habits.