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醋酸环丙氯地孕酮(CA)通过影响垂体促性腺激素分泌或对睾丸和附睾的直接作用而降低生育力,虽然 CA 能导致绝育,但它可引起低睾丸酮血症因而难以在临床上用作男性避孕药。一般认为合并使用 CA 和长效睾丸酮既能有避孕作用又能维持正常的雄性化特征、性欲和性功能。作者研究了合并应用 CA 和睾丸酮庚酸酯(TE)对雄兔的避孕作用并观察了对性欲、性功能及全身的影响。研究采用10～11月龄、体重1.8～2.0kg 的新西兰雄兔。实验分四期:实验前期30天、用药期、
Cyproterone acetate (CA) reduces fertility by affecting the secretion of pituitary gonadotropin or the direct effect on the testis and epididymis, although CA can lead to sterilization, it can cause low testosterone and is therefore difficult to use clinically As a male contraceptives. It is generally believed that the combined use of CA and long-acting testosterone both contraceptives and maintain normal male sexual characteristics, sexual desire and sexual function. The authors studied the contraceptive effects of combined use of CA and testosterone keto-ester (TE) on male rabbits and observed effects on sexual desire, sexual function, and general health. Study using 10 to 11 months old, weighing 1.8 ~ 2.0kg New Zealand male rabbits. The experiment is divided into four periods: the first 30 days of the experiment, the administration period,