贫血动物模型是研究贫血的发病机理、生化紊乱和探索治疗方案的良好工具。现已知制作贫血动物模型的药物有多种,如乙酰胆碱、胆碱、洋葱、苯、苯胼及其衍生物等,但各种药物引起贫血的机理及贫血类型不尽相同。苯可诱发动物再生障碍性贫血和白血病,而苯肼则可引起严重的溶血性贫血。临床上曾一度用苯肼治疗真性红细胞增多症,但以后发现苯肼可导致不同程度的溶血,造成组织、器官的损害,所以临床上已不再使用这种药物,而主要用其制作贫血动物模型。苯肼 The anemia animal model is a good tool to study the pathogenesis of anemia, biochemical disorders and to explore therapeutic options. It is known that there are many kinds of drugs for making animal model of anemia, such as acetylcholine, choline, onion, benzene, benzene and their derivatives, but the mechanism of anemia caused by various drugs and the types of anemia are different. Benzene can induce animal aplastic anemia and leukemia, while phenylhydrazine can cause severe hemolytic anemia. Phenylhydrazine once used to treat polycythemia vera, but later found that phenylhydrazine can lead to varying degrees of hemolysis, resulting in tissue and organ damage, so the clinical no longer use this drug, but mainly used for the production of anemia animals model. Phenylhydrazine