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目的:观察榕根生胶囊的镇痛及对大鼠佐剂性关节炎的抗炎消肿作用。方法:采用弗氏完全佐剂诱导大鼠佐剂性关节炎模型,观察足关节肿胀及炎症指数的改变:采用热板法与扭体法,观察榕根生胶囊对小鼠的镇痛作用。结果:榕根生胶囊能抑制大鼠继发性踝关节炎性肿胀,降低炎症指数;能延长热板法实验中小鼠舔后足的时间,能明显减少醋酸所致小鼠扭体的次数(P<0.05或P<0.01)。榕根生胶囊高剂量组抗炎消肿作用与美洛昔康组无明显差异。结论:榕根生胶囊具有较好的抗炎消肿和镇痛作用。
Objective: To observe the analgesic effect of Qigensheng Capsule and its anti-inflammatory and anti-inflammatory effects on adjuvant arthritis in rats. METHODS: Adjuvant arthritis model induced by Freund’s complete adjuvant was used to observe the changes of foot joint swelling and inflammation index. The analgesic effect of Qigensheng Capsule on mice was observed by hot plate method and writhing method. RESULTS: Qigensheng capsule can inhibit secondary sacroiliitis arthritis in rats and reduce inflammation index. It can prolong the time of spasticity of mice in hot plate test and can significantly reduce the number of writhing caused by acetic acid in mice ( P<0.05 or P<0.01). The anti-inflammatory and anti-tumor effect of Gaogensheng capsule high-dose group was not significantly different from that of meloxicam. Conclusion: Qungensheng Capsule has good anti-inflammatory, swelling, and analgesic effects.