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药物性肝病与病毒性肝炎二者临床表现相似,均有肝功能异常,易导致误诊。1989～1990年收住15例“病毒性肝炎”,经综合分析、最后诊断为药物性肝病。为引起临床家注意,结合文献复习,供鉴别诊断参考。 1 一般资料:15例中男8例、女7例;年龄21岁—70岁。发病前有明确服用损肝药物史,有抗结核药、丹那唑、酮康唑、APC及甲烯土霉素。 2 用药情况:①用抗结核药共9例,其中3例用异菸肼+乙胺丁醇+吡嗪酰胺,用药2～7个月出现症状与肝功能异常;6例用异菸肼+利福平,经3～30天出现症状。这6例内有3例
Clinical manifestations of both drug-induced liver disease and viral hepatitis are similar, both have liver dysfunction, easily lead to misdiagnosis. From 1989 to 1990, 15 cases of “viral hepatitis” were admitted. After comprehensive analysis, the final diagnosis was drug-induced liver disease. To attract clinical attention, combined with the literature review for the differential diagnosis reference. 1 General information: 15 cases of 8 males and 7 females; aged 21 years old -70 years old. Before the onset of a clear history of taking liver medicine, anti-TB drugs, danazol, ketoconazole, APC and methacycline. 2 medication: ① with anti-TB drugs in a total of 9 cases, of which 3 cases with isoniazid + ethambutol + pyrazinamide, medication 2 to 7 months of symptoms and liver dysfunction; 6 cases with isoniazid + Rifampicin, after 3 to 30 days symptoms. There are 3 cases in 6 cases