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目的:研究复方破茎松萝镇痛及对子宫平滑肌的作用。方法:运用醋酸与催产素致痛扭体法研究复方破茎松萝的镇痛作用;运用离体和在体试验研究复方破茎松萝对大鼠子宫收缩活动的影响。结果:复方破茎松萝对醋酸致小鼠扭体反应有一定的镇痛作用,对催产素所致小鼠子宫剧烈收缩引起的疼痛有显著的缓解作用;对大鼠子宫平滑肌(离体和在体)的自发性活动(收缩幅度与收缩频率)有明显的兴奋作用(P<0.05)。结论:复方破茎松萝具有一定的镇痛作用、对大鼠子宫平滑肌有显著的兴奋作用。
OBJECTIVE: To study the analgesic effect of compound Usnea diffracta and its effect on uterine smooth muscle. METHODS: The analgesic effect of Compound Ustila was studied by using acetic acid and oxytocin to induce pain and twisting. The effect of compound Ustila on the uterine contraction was studied in vitro and in vivo. RESULTS: Compound Usnea has a certain analgesic effect on acetic acid-induced writhing in mice, and it has a significant alleviation effect on the pain caused by oxytocin-induced severe contraction of uterus in mice; There was a significant stimulatory effect of spontaneous activity (contraction amplitude and contraction frequency) in the body (P<0.05). Conclusion: The compound spawning Usnea has certain analgesic effect and has a significant excitatory effect on rat uterine smooth muscle.