目的了解氯喹加伯氨喹治疗缅甸拉咱地区间日疟的效果。方法按随机数字表将入选的病人随机分成两组(A组和B组)。A组采用氯、伯氨喹8 d疗法治疗,即成人给予氯喹口服总剂量1 200 mg和伯氨喹口服总剂量180mg;B组采用氯、伯氨喹14 d疗法治疗,即成人给予氯喹口服总剂量1 500 mg或25 mg(基质)/kg体重、伯氨喹口服总剂量210 mg[或0.25 mg(基质)/kg体重]。观察D0(服药后第1 d,之后类推)、D1、D2、D3、D7、D14、D21、D28,及2~6个月的临床疗效和复发情况。结果纳入的129例间日疟患者,111例完成D28随访观察。A、B两组原虫无性体平均转阴时间为(41.05±14.01)h和(35.93±12.62)h,差异有统计学意义(t=2.02,P<0.05);两组平均退热时间为(26.29±10.72)h和(23.46±11.40)h,差异无统计学意义(t=1.454,P>0.05)。A组与B组D1、D2、D3较D0无性体密度下降率分别为92.80%、99.90%、100.0%和94.18%、99.50%、100%。B组在D14随访复查1例原虫复现。A组随访复发率为3.51%(2/57),B组为90.26%(5/54),差异无统计学意义(χ2=0.607,P>0.05)。结论氯喹加伯氨喹两种疗法对缅甸拉咱地区间日疟患者预防复发的效果相同;对该地区的现症间日疟患者采用上述两种疗法治疗效果良好。 Objective To understand the efficacy of chloroquine plus amilorubicin in the treatment of Vivax in Myanmar. Methods The randomized patients were randomly divided into two groups (groups A and B). A group of chlorine, primaquine 8 d therapy, that is, the total dose of oral chloroquine oral administration of 200 mg and oral dose of primaquine 180 mg; B group using chlorine, primaquine 14 d therapy, that is, given orally chloroquine oral The total dose of 1500 mg or 25 mg (matrix) / kg of body weight, total oral dose of primaquine 210 mg [or 0.25 mg (matrix) / kg body weight]. The clinical effects and recurrences of D0 (1 day after administration, and so on), D1, D2, D3, D7, D14, D21, D28, and 2 to 6 months were observed. Results Among 129 cases of vivax malaria patients, 111 cases completed D28 follow-up. The average time of negative conversion of the protozoa in groups A and B was (41.05 ± 14.01) h and (35.93 ± 12.62) h, respectively, with significant difference (t = 2.02, P <0.05) 26.29 ± 10.72) h and (23.46 ± 11.40) h, respectively. The difference was not statistically significant (t = 1.454, P> 0.05). D1, D2 and D3 in group A and group B were 92.80%, 99.90%, 100.0% and 94.18%, 99.50% and 100% lower than that of D0 respectively. In group B, one case of protozoal recurrence was examined at D14. The recurrence rate was 3.51% (2/57) in group A and 90.26% (5/54) ​​in group B, with no significant difference (χ2 = 0.607, P> 0.05). Conclusions Both chloroquine and arquamme regimens have the same effect on preventing recurrence of Plasmodium falciparum in La-Zha area, Myanmar. The treatment with the above-mentioned two therapies against Vivax in the area is effective.