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[目的]探讨肺内良、恶性单纯磨玻璃密度结节(pGGN)的影像学特征及鉴别诊断价值。[方法]收集51例肺内pGGN患者的临床资料及影像学资料,所有患者均经病理及临床随访证实。回顾性分析患者的临床资料、病灶的影像学特点。应用t检验、卡方检验及受试者工作特征曲线计算截断点。[结果]51个pGGN中,良性19个,恶性32个。良、恶性p GGN患者在年龄、性别、吸烟史、病灶的位置间差异无统计学意义(P>0.05)。形态学征象中分叶、空泡、胸膜凹陷征在良、恶性pGGN间差异有统计学意义(P<0.05),而三维比例、毛刺、支气管充气征、血管集束征在良、恶性pGGN间差异无统计学意义(P>0.05)。病灶的大小、质量在良、恶性pGGN中差异有统计学意义(P<0.05)。ROC曲线显示病灶大小、质量诊断恶性pGGN的最佳截断值分别是为10mm、0.16g。[结论]结合病灶的大小、质量以及HRCT特征综合评价pGGN,有利于恶性pGGN的检出。
[Objective] To investigate the imaging characteristics and differential diagnosis of benign and malignant purely glass-densified nodules (pGGN) in the lung. [Methods] The clinical data and imaging data of 51 patients with pGGN in lung were collected. All patients were confirmed by pathology and clinical follow-up. Retrospective analysis of the clinical data of patients, lesions of the imaging features. The truncation points were calculated using t-test, chi-square test, and subject performance curves. [Results] Among the 51 pGGNs, 19 were benign and 32 were malignant. There was no significant difference in age, sex, smoking history and the location of the lesion between benign and malignant pGGN patients (P> 0.05). Morphological signs of lobulation, vacuoles, pleural indentation in benign and malignant pGGN difference was statistically significant (P <0.05), and the three-dimensional ratio, burr, bronchial inflatable sign, vascular bundle sign in the difference between benign and malignant pGGN No statistical significance (P> 0.05). The size and quality of lesions in benign and malignant pGGN were significantly different (P <0.05). ROC curve shows the size of the lesion, the quality of diagnosis of malignant pGGN best cut-off value was 10mm, 0.16g. [Conclusion] The combination of size, quality and HRCT features of pGGN is helpful for the detection of malignant pGGN.