目前,一种药物首次在人体上进行耐受试验以及实验治疗之前,一般要求在药理、生物化学以及毒理学实验室中进行一年以上的试验、这些试验将对药物的疗效、安全性以及可能对人体产生的副作用,甚至毒性提供资料。本文概要地提出药理学实验过程,并举例说明其中的一些问题。发现新药的某些药理学方法如表Ⅰ所示。 At present, for the first time, a drug has to be tested in the human body for tolerability and experimental treatment, it is generally required to carry out more than one year’s experiment in pharmacology, biochemistry and toxicology laboratories. These tests will evaluate the efficacy, safety and possible Side effects on the human body, and even toxicity information. This article presents an overview of the pharmacological experimental procedures and illustrates some of them. Some of the pharmacological methods for discovering new drugs are shown in Table I.