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目的探讨保乳术与根治术治疗乳腺癌的疗效及预后情况。方法选取2011年1月至2014年12月间乌鲁木齐军区总医院收治的161例乳腺癌患者,根据治疗方案不同分为观察组(34例)和对照组(127例),观察组患者采用保乳术治疗,对照组患者采用乳腺癌根治术治疗。两组术后均采用环磷酰胺表柔比星和氟尿嘧啶(CEF)方案化疗联合术后全乳适形调强放疗和瘤床加量放疗方案,对比两组患者术后3年生存率、远端转移率及复发率,并用Karnofsky评分评价两组患者的生活质量。结果观察组患者3年生存率为91.2%,远端转移率为5.9%,复发率为8.8%,对照组患者3年生存率为93.7%,远端转移率为5.5%,复发率为7.9%,两组组间比较,差异无统计学意义(P>0.05)。术前,两组患者的Karnofsky评分组间比较,比较差异无统计学意义(P>0.05),术后1年、3年时观察组和对照组的Karnofsky评分分别为(78.6±6.8)分、(85.4±5.5)分和(72.9±6.4)分、(75.6±6.5)分,观察组均高于对照组,两组组间比较,差异有统计学意义(P<0.05)。结论保乳术联合术后放化疗治疗乳腺癌的疗效与根治术联合术后放化疗的疗效相当,且具有创伤小和恢复快的优势,患者术后生活质量较高。
Objective To investigate the efficacy and prognosis of breast-conserving surgery and radical mastectomy for breast cancer. Methods A total of 161 breast cancer patients admitted to Urumqi Military General Hospital from January 2011 to December 2014 were selected and divided into observation group (34 cases) and control group (127 cases) according to the treatment plan. The observation group was treated with breast-conserving The patients in the control group were treated with radical mastectomy. Two groups of patients were treated with cyclophosphamide epirubicin and fluorouracil (CEF) chemotherapy combined with postoperative gynecomastia intensity modulated radiation therapy and tumor bed dose of radiotherapy program, compared the two groups of patients after 3-year survival rate, far End metastasis rate and recurrence rate, and Karnofsky score was used to evaluate the quality of life of the two groups. Results The 3-year survival rate was 91.2% in the observation group, 5.9% in the distant metastasis, 8.8% in the recurrence, 93.7% in the control group, 5.5% in the distant metastasis, and 7.9% in the distant metastasis There was no significant difference between the two groups (P> 0.05). The Karnofsky scores of the two groups were not significantly different before surgery (P> 0.05). The Karnofsky scores of the observation group and the control group at 1 year and 3 years after operation were (78.6 ± 6.8) (85.4 ± 5.5) points and (72.9 ± 6.4) points and (75.6 ± 6.5) points respectively. The observation group was higher than the control group. There was significant difference between the two groups (P <0.05). Conclusions The efficacy of breast-conserving surgery combined with postoperative radiotherapy and chemotherapy in the treatment of breast cancer is similar to that of radical operation combined with postoperative chemoradiotherapy. It has the advantage of small trauma and rapid recovery, and has higher postoperative quality of life.