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兔于感染日本血吸虫尾蚴后d7灌服(ig)1次蒿甲醚(Art)30mg·kg-1,并于感染后d14、d21、d35和d49重复ig1次相同剂量的Art时,在兔肝的切片中仅查见死虫,未见有虫卵或和虫卵性肉芽肿形成。若于感染后d7、d21、d35和d49ig上述剂量的Art1次时,肝内偶而查见少量虫卵和虫卵性肉芽肿。若于感染后d21ig1次吡喹酮(Pra)40mg·kg-1,然后每wk(d28和d35)或每2wk(d35和d49)重复ig1次相同剂量的Pra时,前者肝切片查见的虫卵数和虫卵肉芽肿远较对照组的为少,但较后者为多,后者所查见的为陈旧性虫卵或虫卵性芽肿。结果表明兔于感染血吸虫尾蚴后,用Art或Pra早期治疗,因大部分或甚至全部♀虫被杀死,肝脏受虫卵损害轻微或无明显损害。
Rabbits were infected with S. japonicum cercariae d7 once (ig) artemether (Art) 30mg · kg-1, and after infection d14, d21, d35 and d49 repeat ig1 the same dose of Art, the rabbit liver See only dead insects section of the chip, no eggs or egg granuloma formation. If the infection at the d7, d21, d35 and d49ig doses of Art1 times, the liver occasionally see a small amount of eggs and egg granuloma. If p21 was treated with p21,21 praziquantel (Pra) 40 mg · kg-1 at d21ig and then the same dose of Pra was repeated every wk (d28 and d35) or every 2 weeks (d35 and d49) after infection, The number of eggs and granuloma of the egg far than the control group is less, but more than the latter, the latter is seen as old or ovum egg bud. The results showed that rabbits were treated early with Art or Pra after infected with Schistosoma japonicum, and most or even all of the pinworms were killed, with little or no damage to the liver by the eggs.