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瘦素(leptin)是肥胖基因(ob基因)编码的产物,由白色脂肪组织分泌入血。leptin与leptin受体结合,通过JAK-STAT途径发挥生理作用,不仅能调节食欲、控制饮食、抑制脂肪合成、促进脂肪分解、调控能量代谢,还可影响女性生殖内分泌系统,调节下丘脑-垂体-卵巢轴,影响生殖功能及女性排卵,参与青春期的启动,是连接营养与生殖的代谢信号。就leptin对女性生殖内分泌的影响的研究进展作一综述。
Leptin is a product of the obesity gene (ob gene), secreted into the blood by white adipose tissue. Leptin binds to the leptin receptor and exerts physiological effects through the JAK-STAT pathway. It not only regulates appetite, controls diet, inhibits fat synthesis, promotes lipolysis, regulates energy metabolism, but also affects female reproductive and endocrine systems and regulates hypothalamic-pituitary- Ovarian axis, affecting reproductive function and female ovulation, involved in the start of puberty, is a metabolic signal linking nutrition and reproduction. The research progress of leptin on female reproductive and endocrine effects is reviewed.