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目的:分析含朱砂中成药中微量元素的含量并初步探讨这些中成药临床疗效与微量元素的关系。方法:样品经湿法消解后,采用ICP-OES法测定4种含朱砂中成药中微量元素的含量。结果:柏子养心丸、天王补心丸、补肾益脑丸、七厘胶囊等4种中成药均含有Co、Cr、Cu、Fe、Mn、Zn、B、As、Pb、Hg、Cd和Tl等12种微量元素,其中柏子养心丸与天王补心丸富含Fe、Mn元素,七厘胶囊的Fe、Mn、Zn、B、Cr、Co等元素的含量高于其他3种中成药。4种中成药的Hg元素含量均大大超出限量标准,补肾益脑丸富含Cu元素含量略超标。结论:这些中成药的疗效可能与其所含的微量元素相关,且临床使用应注意控制剂量以保证安全。
Objective: To analyze the content of trace elements in Chinese medicine containing cinnabar and to probe the relationship between clinical efficacy and trace elements of these proprietary Chinese medicines. Methods: After the sample was digested by wet method, the contents of trace elements in four kinds of Chinese herbal medicines containing cinnabar were determined by ICP-OES. Results: Four kinds of proprietary Chinese medicines, including Bozi Yangxin Wan, Tianwang Buxin Wan, Bushen Yiren Wan and Qili Capsule, contained Co, Cr, Cu, Fe, Mn, Zn, B, As, Pb, Hg, Cd and Tl The contents of Fe, Mn, Zn, B, Cr, Co and other elements in Qili Capsule were higher than the other three kinds of proprietary Chinese medicines. The contents of Hg in four kinds of proprietary Chinese medicines were greatly exceeded the limit standards, and the content of Cu element in Bushen Yiren Pill slightly exceeded the standard. Conclusion: The efficacy of these proprietary Chinese medicines may be related to the trace elements contained in them, and clinical use should pay attention to dosage control to ensure safety.