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目的探讨药物性肾病在我国住院患者人群中发生率及与筛选出其可疑药物。方法利用2009年5月29日至12月31日医院住院患者用药数据库(IDUD)信息,采用数据挖掘技术结合药物流行病学研究方法,计算药物性肾病与可疑药物之间相对危险度。结果共获得药物性肾病的可疑药物130个,其中中药49个。按相对危险度排序,前3位可疑药物分别为扶正化瘀、肾衰宁和精氨酸。结论在住院患者人群中,特别是使用中药的患者,应加强肾功能监测。
Objective To investigate the incidence of drug-induced nephropathy in hospitalized patients in China and to screen out its suspicious drugs. Methods The data of inpatient database (IDUD) from May 29, 2009 to December 31, 2009 were used to calculate the relative risk of drug-induced nephropathy and suspected drug using data mining techniques and epidemiological study. Results A total of 130 drug-induced nephropathy suspicious drugs, of which 49 Chinese medicine. According to the relative risk ranking, the first three suspicious drugs were Fuzhenghuayu, Shenshuainin and Arginine. Conclusion In patients with inpatients, especially in patients with traditional Chinese medicine, renal function monitoring should be strengthened.