左旋氧氟沙星（levofloxacin，LVFX）是新一代隆诺团抗菌药物，为氧氟沙星的S型左旋光学异构体，抗菌活性是氧氟沙星的2倍，临床毒副反应远低于氧氛沙星［’］。本文选用0．3％LVFX给家兔点眼，观察其眼内通透性，并进行限内药代动力学分析，为临床开发用药提供理论依据。材料 Levofloxacin (LVFX) is a new generation of Lonicera antibacterial drugs, ofloxacin S-type L-optical isomers, antibacterial activity is ofloxacin 2 times, clinical toxicity is far lower In the oxygen sand star [’]. In this paper, 0.3% LVFX was used to spot the eyes of rabbits and their intraocular permeability was observed. The pharmacokinetic analysis was conducted within limits to provide a theoretical basis for the clinical development of drugs. material