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加压素(Vasopressin,VP或ADH)是下丘脑视上核和室旁核合成的九肽激素,经轴浆运输至垂体后叶释放,因此又被认为是垂体后叶激素之一。1895年Oliver和Sehaefer首先发现VP,1928年Kamm等才将它成功地分离出来。1951年它成为第一个被人工合成的肽类激素;1954年Du Vignaud由于成功地合成VP而获得诺贝尔奖金。
Vasopressin (VP or ADH), a nonapeptide hormone synthesized in the supraoptic nucleus and paraventricular nucleus of the hypothalamus, is transported by axoplasm to the posterior pituitary and is therefore considered as one of the pituitary hormones. Oliver and Sehaefer first discovered VP in 1895 and Kamm et al. In 1928 successfully separated it. It became the first synthetic peptide hormone in 1951; Du Vignaud won a Nobel Prize in 1954 for the successful synthesis of VP.