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目的研究儿童白血病深部真菌感染的临床特征及治疗效果。方法对５０例急性白血病实施强烈化疗，可疑病人作真菌培养等检查，并提出深部真菌感染的诊断方法及疗效标准，对确诊深部真菌感染的病例以氟康唑治疗，并采取积极的支持治疗及抗生素预防治疗。结果５０例患者中２１例２２例次发生深部真菌感染，全部病例均有严重的骨髓抑制及高热，予氟康唑治疗，治愈率８６．４％，无明显毒副作用；深部真菌感染的发生与粒细胞减少程度以及持续时间有关，与疾病的种类无关，Ｐ＞０．０５；缓解前的诱导治疗较缓解后的巩固强化治疗易发生深部真菌感染，Ｐ＜０．０１。结论中性粒细胞严重减少的病人易发生深部真菌感染，诱导治疗阶段尤为多见，氟康唑是治疗深部真菌感染的有效药物
Objective To study the clinical characteristics and therapeutic effects of deep fungal infection in childhood leukemia. Methods Fifty cases of acute leukemia were treated with intensive chemotherapy and the suspicious patients were tested for fungal culture. The diagnostic methods and efficacy criteria of deep fungal infection were proposed. Fluconazole was used in the diagnosis of deep fungal infection and the patients were treated with active supportive therapy Antibiotic prophylaxis and treatment. Results Of the 50 patients, 21 cases developed deep fungal infection in 22 cases. All patients had severe myelosuppression and hyperthermia. The treatment with fluconazole resulted in a cure rate of 86.4% with no obvious toxic or side effects. The occurrence of deep fungal infection was associated with Neutropenia and duration of neutropenia, but not related to the type of disease, P> 0.05; induction therapy before remission was more likely to develop deep fungal infection than consolidation therapy after remission, P <0.01. Conclusions Deep neutrophilic infections are more likely to occur in patients with severe neutropenia, especially during induction therapy. Fluconazole is an effective drug for the treatment of deep fungal infections