骨髓间充质干细胞是主要存在于骨髓中的一种具有多向分化潜能的干细胞。近年来干细胞移植治疗缺血性脑卒中的实验研究显示其能有效改善由于脑卒中等中枢神经系统疾病所致的神经功能缺损,作为神经干细胞的来源,骨髓间充质干细胞用于缺血性脑卒中的治疗具有广阔的前景。本文从骨髓间充质干细胞的特点、移植的可行性、在缺血性脑卒中的研究进展及其作用机制等方面进行综述。 Bone marrow mesenchymal stem cells (MSCs) are a type of stem cell that has multidirectional differentiation potential mainly in bone marrow. In recent years, stem cell transplantation in the treatment of ischemic stroke experimental studies have shown that it can effectively improve the central nervous system diseases due to stroke and other neurological deficits, as a source of neural stem cells, bone marrow mesenchymal stem cells for ischemic brain Stroke treatment has broad prospects. This article reviews the characteristics of bone marrow mesenchymal stem cells, the feasibility of transplantation, the research progress in ischemic stroke and its mechanism of action.