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CD154是CD40的配体,主要表达在CD4+T细胞表面,是免疫反应中重要的协同刺激因子之一。特发性血小板减少性紫癜(idiopathicthrombocytopenic purpuraITP)是一种以产生自身抗体而导致血小板减少为特征的自身免疫性疾病,其发病机制至今仍不完全清楚。近期的研究发现细胞免疫在ITP发
CD154, a ligand of CD40, is mainly expressed on the surface of CD4 + T cells and is one of the important costimulatory factors in immune response. Idiopathic thrombocytopenic purpuraITP is an autoimmune disease characterized by autoantibodies leading to thrombocytopenia. The pathogenesis of idiopathic thrombocytopenic purpura is still not fully understood. Recent studies have found that cellular immunity occurs in ITP