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目的观察神经节苷脂对新生儿缺氧缺血性脑病(HIE)的临床疗效,探讨治疗该病的新疗法。方法将临床确诊的300例HIE患儿随机分为对照组和神经节苷脂治疗组(治疗组),每组150例,两组均给予常规综合治疗,治疗组在综合治疗的基础上加用神经节苷脂20 mg/d,疗程轻度7d,中度疗程10~14d,重度疗程3~4周,于治疗后14、28d用NBNA评分评估治疗效果。结果治疗组于治疗后14d、28 dNBNA评分均优于对照组(P<0.01)。结论神经节苷脂治疗新生儿缺氧缺血性脑病,安全有效,值得临床推广应用。
Objective To observe the clinical efficacy of gangliosides on neonatal hypoxic-ischemic encephalopathy (HIE) and to explore new therapies for the treatment of this disease. Methods 300 cases of HIE clinically diagnosed were randomly divided into control group and ganglioside treatment group (treatment group), 150 cases in each group, both groups were given conventional comprehensive treatment, the treatment group based on the combined treatment with Ganglioside 20 mg / d, mild treatment for 7d, moderate treatment for 10 ~ 14d, severe treatment for 3 ~ 4 weeks, after treatment 14,28d with NBNA score to evaluate the therapeutic effect. Results The score of NBNA in the treatment group at 14d and 28d after treatment was better than that in the control group (P <0.01). Conclusion Ganglioside treatment of neonatal hypoxic-ischemic encephalopathy, safe and effective, worthy of clinical application.