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目的 :探讨 2型糖尿病微血管病变与血浆内皮素 (ET)及血管性假血友病因子 (vWF)的关系。方法 :采用放射免疫法 (RIA)及双抗酶联免疫法 (ELISA)测定 12例正常人及 4 9例 2型糖尿病患者的血浆ET及vWF水平。结果 :糖尿病组血浆ET及vWF水平较正常人升高 ;糖尿病有微血管病变组较糖尿病无并发症组升高更明显。结论 :血浆ET及vWF水平的升高与糖尿病微血管病变的发生发展有关
Objective: To investigate the relationship between type 2 diabetic microangiopathy and plasma endothelin (ET) and von Willebrand factor (vWF). Methods: Plasma ET and vWF levels were measured in 12 normal subjects and 49 patients with type 2 diabetes by radioimmunoassay (RIA) and double enzyme-linked immunosorbent assay (ELISA). Results: The levels of plasma ET and vWF in diabetic patients were higher than those in normal subjects. The patients with diabetic microangiopathy had more obvious increase than diabetic patients without complications. Conclusion: The increase of plasma ET and vWF levels is associated with the occurrence and development of diabetic microangiopathy