论文部分内容阅读
文章简介Treg细胞在免疫系统的稳态调节和自身免疫疾病中发挥重要作用,其缺失会造成小鼠和人类致死性的自身免疫疾病。而TCR和细胞因子等信号对于Treg细胞的稳态增殖和免疫抑制功能至关重要,这些信号传递过程在转录、翻译和翻译后水平受到多重调控。其中,SUMO化修饰是一种存在于真核细胞中的蛋白翻译后修饰,其特征是在
INTRODUCTION Treg cells play an important role in the homeostasis of the immune system and autoimmune diseases, and their absence causes fatal autoimmune diseases in mice and humans. Signals such as TCR and cytokines are crucial for the steady-state proliferation and immunosuppression of Treg cells. These signaling processes are heavily regulated at the transcriptional, translational, and posttranslational levels. Among them, SUMO modification is a protein post-translational modification existing in eukaryotic cells, characterized by