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紫杉醇（Ｐａｃｌｉｔａｘｅｌ）剂量设５４、１８和６ｍｇ／ｋｇ三个实验组，同时设溶剂对照组、生理盐水对照组和环磷酰胺（Ｃｙｃｌｏｐｈｏｓｐｈａｍｉｄｅ．ＣＰ）６ｍｇ／ｋｇ为阳性对照组。小鼠于孕期ｄ６皮下注射给药，连续给药五ｄ，每ｄ一次。于孕期ｄ１１．５处死母鼠，结果表明，紫杉醇各剂量组小鼠早期胚胎的生长发育和形态发育指标与溶剂对照和生理水对照相比均有非常明显的差别。与给药剂量有关，剂量增加影响更明显。对胚胎组织匀浆生化分析发现５４ｍｇ／ｋｇ组ＳＴ和ＬＤＨ升高，ＡＬＰ和ＴＰ明显下降。１８ｍｇ／ｋｇ组ＡＬＰ和ＴＰ下降，ＬＤＨ升高。６ｍｇ／ｋｇ组ＡＬＰ下降ＬＤＨ升高，与溶剂对照组相比均有统计学差异。
The paclitaxel doses were set at 54, 18, and 6 mg/kg in three experimental groups. The solvent control group, physiological saline control group, and Cyclophosphamide (CP) 6 mg/kg were used as positive control groups. Mice were given subcutaneous injections during d6 during pregnancy and administered continuously for five days, once per d. The maternal mice were sacrificed at d11.5 during pregnancy. The results showed that there were significant differences in the growth, development, and morphological development of the mouse embryos at each dose of paclitaxel compared with the solvent control and the physiological water control. In relation to the dose administered, the effect of dose increase is more pronounced. The biochemical analysis of homogenates of embryos found that ST and LDH increased in 54 mg/kg group, and ALP and TP decreased significantly. The ALP and TP in the 18 mg/kg group decreased, and the LDH increased. In the 6mg/kg group, the LDH decreased, and there was a statistically significant difference compared with the solvent control group.