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在电生理研究(EPS)指导下使用抗心律失常药物的病人之中,由于室性心动过速(VT)复发或药物不能耐受而需改变用药的发生率尚不明了,本文研究这一发生率。 方法 138例病人均在停用抗心律失常药(至少五个半衰期)后作基础EPS,用程序电刺激法(PES)诱发VT或Vf。随后作一系列的药物试验。在口服药物达到稳态水平后再重复PES,先用I_a类抗心律失常药,无效则更换另一I_a类药或与I_b类药合用,仍无效
Among patients who use anti-arrhythmic drugs under the direction of electrophysiological studies (EPS), the incidence of medication change due to recurrent ventricular tachycardia (VT) or drug intolerance is unknown, and this study examines this rate. Methods All 138 patients underwent basic EPS after discontinuation of antiarrhythmic drugs (at least five half-lives) and VT or Vf was induced by procedural electrical stimulation (PES). Then for a series of drug tests. After the oral drug reaches steady state level and then repeat the PES, first with I_a class antiarrhythmic drugs, the ineffective replacement of another I_a class of drugs or with I_b class of drugs, is still invalid