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目的 探讨长期多次接触氡温泉对人群氧化损伤及抗氧化水平的影响.方法 简单随机抽样法选取平山氡温泉周边居民46人作为氡温泉组,选取回舍镇居民39人作为对照组.采用酶联免疫吸附测定(ELISA)检测血浆中8-OHdG和TrxR的水平.采用Mann-Whitney U检验比较两组间8-OHdG和TrxR的差异性表达.结果 氡温泉组居民外周血血浆中8-OHdG水平明显降低,TrxR水平明显升高(Z=-3.350,-2.394,P＜0.05),分别是对照组的0.622倍,1.373倍.多重线性回归分析显示校正了年龄、抽烟、饮酒、饮茶、BMI等因素之后,居民氡暴露因素与8-OHdG和TrxR的差异性表达相关(t=-3.188,2.267,P＜0.05).结论 长期多频次接触氡温泉可在一定程度上增强机体抗氧化能力,降低机体氧化损伤水平.“,”Objective To investigate the effects of long-term and repeatedly exposure to radon hot spring on oxidative damage and antioxidation in the population.Methods A simple random sampling method was used to select 46 residents around Radon Hot Spring in Ping Shan county as radon group,and 39 residents of Huishe township were selected as control group.Plasma levels of 8-OHdG and TrxR were measured by enzyme-linked immune sorbent assay (ELISA).The Mann-Whitney U test was used to compare the differential expression of 8-OHdG and TrxR between the two groups.Results The levels of 8-OHdG in peripheral plasma of residents with radon group were significantly decreased,and the levels of TrxR were significantly increased (Z =-3.350,-2.394,P ＜ 0.05),which were 0.622 times and 1.373 times that of the control group respectively.After the multiple linear regression analysis adjusted the factors of age,smoking,drinking,drinking tea and BMI,and residents radon exposure was associated with the differential expression of 8-OHdG and TrxR (t =-3.188,2.267,P ＜ 0.05).Conclusion Long-term and repeatedly exposure to radon hot springs can enhance the antioxidant capacity to a certain extent,and reduce the level of oxidative damage.