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报道1例海洛因海绵状白质脑病的临床和病理，并复习文献进行分析。 海洛因海绵状白质脑病具有如下特点：有经鼻吸海洛因史；亚急性或急性起病；多以小脑受损为首发症状，亦可表现为突然昏迷、抽搐；以运动障碍为主；脑脊液正常；尿吗啡实验可为阴性；影像学具有特征性的脑白质广泛受累，小脑白质受累最早、最严重，病变双侧对称，CT呈低密度，无占位效应，增强无强化。主要病理改变为脑白质海绵状变性。推测病因可能与海洛因不纯含有杂质有关。有海洛因吸入史者，一旦出现脑部症状，要及早行影像学检查，明确诊断。本病为我国大陆第1次在海洛因吸食者中发现，对预防和治疗吸毒所引起的并发症有指导意义。
A case of herpes cavernous leukoencephalopathy clinical and pathological reports, and review the literature for analysis. Heroin sponge leukoencephalopathy has the following characteristics: nasal heroin history; subacute or acute onset; more damage to the cerebellum as the first symptom can also be manifested as sudden coma, convulsions; mainly dyskinesia; normal cerebrospinal fluid; Urine morphine experiment can be negative; imaging features of a broad involvement of white matter, white matter involvement of the earliest and most serious lesions bilateral symmetry, CT was low density, no mass effect, enhanced without enhancement. The main pathological changes of white matter sponge degeneration. It is speculated that the cause may be related to heroin impure impurities. A history of heroin inhalation, once the brain symptoms, as early as possible imaging examination, a clear diagnosis. The disease for the first time in mainland China found in heroin abusers, the prevention and treatment of drug-induced complications Guidance.