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报道了多次口灌呋喃唑酮(60 mg/kg,连续3 d,每天1次)在草鱼体内血浆、肌肉、肝脏和肾脏中的消除与残留研究。采用高效液相色谱法(HPLC)检测用药后不同时间各组织中药物浓度,M ILLEMNIUM32工作站处理原始数据,MCPKP药代动力学软件处理药时数据。结果表明:多次口灌呋喃唑酮在草鱼体内的药时数据符合一级速率吸收一室开放模型,其主要药动学参数为:AUC 2.3182μg.h/m l,Cmax 0.850μg/m l,Ka 0.5515 h-1,K 0.0936 h-1,T1/2ka1.2565h,T1/2k7.4308h,Tp 2.8732 h,药物在血浆、肌肉、肝脏、肾脏中消除时间分别为:72 h、15 d、20 d、20 d。
Reported the elimination and residual studies of multiple daily doses of furazolidone (60 mg / kg, once daily for 3 days) in the plasma, muscle, liver and kidney of grass carp. The drug concentration in each tissue at different time after drug administration was detected by high performance liquid chromatography (HPLC), raw data was processed by M ILLEMNIUM32 workstation and the pharmacokinetic data were processed by MCPKP pharmacokinetics software. The results showed that the pharmacokinetic parameters of furazolidone in grass carp were consistent with the first-rate rate one-compartment open model. The main pharmacokinetic parameters were as follows: AUC 2.3182μg.h / ml, Cmax 0.850μg / ml, Ka 0.5515 h T1, 2k7.4308h, Tp2.8732h, respectively. The elimination time of drugs in plasma, muscle, liver and kidney were 72 h, 15 d, 20 d, 20 d.