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目的分析妊娠期糖尿病患者胎盘组织中TNF-α的表达。方法采用免疫组化染色技术,检测了31例妊娠期糖尿病患者(GDM组)及30例正常妊娠妇女(正常妊娠组)胎盘组织中TNF-α的表达情况。结果GDM组胎盘TNF-α的表达显著高于正常妊娠组。结论TNF-α的表达与妊娠期糖尿病的发生、发展有关,其机制尚需进一步研究。
Objective To analyze the expression of TNF-α in placenta of gestational diabetic patients. Methods Immunohistochemical staining was used to detect the expression of TNF-α in placenta of 31 gestational diabetes mellitus patients (GDM group) and 30 normal pregnant women (normal pregnancy group). Results The expression of TNF-α in placenta of GDM group was significantly higher than that in normal pregnancy group. Conclusions The expression of TNF-α is related to the occurrence and development of gestational diabetes mellitus. The mechanism needs to be further studied.