论文部分内容阅读
目的探讨趋化因子IL-8及MCP-1在结直肠癌患者血清中的表达及临床意义。方法通过悬浮芯片系统检测结直肠癌患者术前术后及正常人血清中趋化因子IL-8及MCP-1表达的变化。结果结直肠癌患者血清中趋化因子IL-8的含量与正常对照组相比显著升高,而手术治疗后,表达有所降低,但仍较正常对照组高;趋化因子MCP-1的含量与正常对照组相比显著降低,而手术治疗后,表达有所升高,但仍较正常对照组低;趋化因子IL-8及MCP-1与结直肠癌的临床分期及预后明显相关,而与性别、年龄、肿瘤大小及侵袭范围无关。结论外周血清中趋化因子IL-8及MCP-1的含量能够反映结直肠癌患者机体的肿瘤负荷状态,与结直肠癌的浸润、转移及复发相关,在结直肠癌的筛查方面有一定意义。
Objective To investigate the expression of chemokines IL-8 and MCP-1 in the serum of patients with colorectal cancer and its clinical significance. Methods The changes of chemokines IL-8 and MCP-1 in serum of colorectal cancer patients before and after surgery were detected by suspension chip system. Results The level of chemokine IL-8 in serum of patients with colorectal cancer was significantly higher than that of the normal control group, but decreased after operation, but still higher than that of the normal control group. Chemokine MCP-1 Compared with the normal control group, the expression of IL-8 and MCP-1 was significantly lower than that of the normal control group, but the expression of MCP-1 and MCP-1 were significantly correlated with the clinical stage and prognosis of colorectal cancer , Regardless of gender, age, tumor size and extent of invasion. Conclusion The levels of chemokines IL-8 and MCP-1 in peripheral blood can reflect the tumor burden of colorectal cancer patients, which is related to the invasion, metastasis and recurrence of colorectal cancer, significance.