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作者报告了前生长抑素(Prosomtostatin、pro-ss)与生长抑素(ss)在诱导生长激素(GH)和催乳素(PRL)释放及影响血糖水平方面的对照研究。随着对ss 分离、结构、合成及生物学活性研究的进展,发现动物丘脑下及肠胃道存在活性型ss。据认为该物质系与ss 同源的前体或另一种分泌型式。这种由ss 的N 端延伸的28肽已从猪肠、丘脑下提取。并可用固相法合成供活体及体外生物学效应研究。该28肽结构中包含14
The authors report a prospective controlled study of the effects of prosomostatin (pro-ss) and somatostatin (ss) on the induction of growth hormone (GH) and prolactin (PRL) release and their effects on blood glucose levels. With the progress of the research on ss separation, structure, synthesis and biological activity, it is found that there exists active ss in thalamus and gastrointestinal tract in animals. It is thought that the substance is a precursor or another secreted form that is homologous to ss. This 28-terminal peptide extending from the N-terminus of ss has been extracted from porcine intestine and subthalamic area. And solid phase synthesis can be used for living and in vitro biological effects. This 28 peptide structure contains 14