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为探讨川芎嗪和尼莫地平在心脑血管疾病防治中的作用机制，我们采用内皮细胞体外培养的方法，观察尼莫地平和川芎嗪对内皮细胞分泌内皮素（ET）和一氧化氮（NO）的影响。实验结果发现，两药均能不同程度地抑制正常体外培养的内皮细胞产生内皮素，改变ET和NO的比例，从而起到防治心脑血管疾病的作用。
To explore the mechanism of ligustrazine and nimodipine in the prevention and treatment of cardiovascular and cerebrovascular diseases, we used endothelial cell culture in vitro to observe the effect of nimodipine and ligustrazine on the secretion of endothelin (ET) and nitric oxide (NO) )Impact. The experimental results showed that both drugs can inhibit the endothelial cells in normal cultured endothelial cells to varying degrees, changing the ratio of ET and NO, which play a role in prevention and treatment of cardiovascular and cerebrovascular diseases.