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概述 1957年丙咪嗪首次用于治疗抑郁症后,已有60余种新的抗抑郁剂被临床应用。对这些药物的药理和疗效研究导致了抑郁症生化理论的进展。 从老的抗抑郁剂的药理性质中引出抑郁症生化理论的假说有以下3种:(1)抑郁症是由去甲肾上腺素(NA)或5-羟色胺(5-HT)
Summary After the first use of imipramine in 1957 for the treatment of depression, more than 60 new antidepressants have been clinically used. The pharmacological and therapeutic effects of these drugs have led to the development of biochemical theory of depression. There are three hypotheses that lead to the biochemical theory of depression from the pharmacological properties of older antidepressants: (1) Depression is caused by norepinephrine (NA) or serotonin (5-HT)