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采用先进的图像分析系统观察中药大黄提取物Ⅰ号对链脲菌素(STZ)所致的糖尿病肾病大鼠模型肾小球形态学的影响。结果提示病程第3天模型组大鼠肾小球平均体积较治疗组大鼠明显增大(P<0.01);病程的第3、7、14天,模型组大鼠肾小球系膜区平均面积较治疗组扩大,(P<0.01)。本研究在实验性大鼠的体内进一步证实大黄提取物Ⅰ号抑制肾脏肥大的作用。
An advanced image analysis system was used to observe the effect of rhubarb extract No.1 on the glomerular morphology of rats with diabetic nephropathy induced by streptozotocin (STZ). The results suggested that the average glomerular volume in the model group rats on the 3rd day of the disease course was significantly greater than that in the treatment group (P<0.01). On the 3rd, 7th, and 14th days of the disease course, the glomerular mesangial area of the model group was averaged. The area was larger than that of the treatment group (P<0.01). This study further confirmed the effect of rhubarb extract I on inhibiting renal hypertrophy in the body of experimental rats.