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目的探讨急性心肌梗死(AMI)患者血浆中B型脑钠肽(B typenatriureticpeptide,BNP)水平变化的临床意义。方法选择住院患者60例,其中40例为急性心肌梗死患者(AMI组间与A组),20例为冠状动脉造影正常的对照组(E组)。根据心功能Killip分级将患病组分为,Killip1级(K1组)15例,Killip2级(K2组)12例和Killip3级(K3组)13例及Killip4级(K4组)。结果AMI心功能Killip3级组、Killip2级组及Killip1级组血浆BNP浓度分别高于Killip2级组、Killip1级组和对照组(P<0·05,P<0·05,P<0·01);冠脉3支病变组BNP浓度高于1支病变组(P<0·05)。结论患者心衰越重BNP的水平越高,BNP是反映心功能不全的有效指标,BNP可以作为急性冠脉综合征患者判断心功能和评估愈后的指标。
Objective To investigate the clinical significance of plasma B-type natriuretic peptide (BNP) levels in patients with acute myocardial infarction (AMI). Methods Sixty patients were selected as inpatients, 40 of them were patients with acute myocardial infarction (AMI group and A group) and 20 were normal coronary angiography (E group). According to Killip classification, 15 cases were classified as Killip class 1 (K1 group), 12 cases were Killip class2 (K2 group), 13 cases were Killip class3 (K3 group) and Killip4 class (K4 group). Results The BNP levels in Killip3, Killip2 and Killip1 groups were significantly higher than those in Killip2 group, Killip1 group and control group (P <0.05, P <0.05, P <0.01) ; BNP concentration in 3 lesions of coronary artery was higher than that in 1 lesions (P <0.05). Conclusions The higher BNP level in patients with heart failure, BNP is a valid indicator of cardiac insufficiency. BNP can be used as an indicator of cardiac function and prognosis in patients with acute coronary syndrome.