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目的:观察解整合素-金属蛋白质酶12-S(ADAM12-S)在异位妊娠及正常妊娠过程中的变化特点,探讨ADAM12-S在异位妊娠早期诊断中的临床应用价值。方法:146例异位妊娠患者作为异位妊娠组,263例正常孕妇作为对照组,观察两组研究对象ADAM12-S的检测情况。结果:异位妊娠组平均ADAM12-S对数值在不同孕周均低于同期正常妊娠组(P<0.05);263例正常对照组妊娠妇女ADAM12-S对数值与孕周呈线性关系(r=0.926,P=0.000),回归方程y=0.3147x-0.3099,ADAM12-S对数值随孕周增加而上升;146例异位妊娠ADAM12-S对数值与孕周无明显线性关系(r=-0.119,P=0.140)。结论:ADAM12-S在妊娠早期阶段能较好地反映胎盘功能情况,异位妊娠胎盘功能低下,ADAM12-S可作为异位妊娠诊断的辅助检查手段。
Objective: To observe the changes of ADAM12-S in ectopic pregnancy and normal pregnancy, and to explore the clinical value of ADAM12-S in the early diagnosis of ectopic pregnancy. Methods: 146 cases of ectopic pregnancy as ectopic pregnancy group, 263 cases of normal pregnant women as a control group to observe the two groups of subjects ADAM12-S detection. Results: The mean ADAM12-S logarithm of ectopic pregnancy group was lower than that of the normal pregnancy group at different gestational weeks (P <0.05). There was a linear relationship between ADAM12-S logarithm and gestational age of 263 normal pregnant women (r = 0.926, P = 0.000). The regression equation y = 0.3147x-0.3099. The logarithm value of ADAM12-S increased with the increase of gestation week. There was no significant linear relationship between ADAM12-S logarithm and gestational age in 146 cases of ectopic pregnancy (r = -0.119 , P = 0.140). CONCLUSION: ADAM12-S can better reflect the function of placenta in early pregnancy, placental dysfunction in ectopic pregnancy, ADAM12-S can be used as an auxiliary examination for the diagnosis of ectopic pregnancy.