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目的探讨热休克蛋白70(HSP70)在侵袭性葡萄胎化疗子宫内膜中的表达及其与预后的关系。方法采用免疫组织化学法,分别检测34例侵袭性葡萄胎患者的子宫内膜标本中化疗前后HSP70的表达,并进行定期随访追踪检测。结果HSP70在侵袭性葡萄胎患者子宫内膜中过度表达,其表达与病理分期呈正相关(P<001),与化疗后近期疗效呈正相关(P<001),但高表达组与低表达组相比,无病生存期显著降低(P<001)。结论子宫内膜中HSP70表达水平可作为侵袭性葡萄胎转归及化疗疗效判定的指标。
Objective To investigate the expression of heat shock protein 70 (HSP70) in invasive hydatidiform mole in endometrium and its relationship with prognosis. Methods Immunohistochemical method was used to detect the expression of HSP70 in 34 cases of invasive hydatidiform mole before and after chemotherapy. The patients were followed up regularly. Results The expression of HSP70 was overexpressed in the endometrium of invasive hydatidiform mole. The expression of HSP70 was positively correlated with the pathological stage (P <001), and positively correlated with the short-term efficacy after chemotherapy (P <001) The disease-free survival was significantly lower than that of the control group (P <001). Conclusion The expression level of HSP70 in endometrium can be used as an index of the outcome of invasive hydatidiform mole and chemotherapy.