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目的比较三联疗法阿莫西林双氯西林钠胶囊、埃索美拉唑镁肠溶片、克拉霉素片和阿莫西林钠胶囊、埃索美拉唑镁肠溶片、克拉霉素片根除幽门螺杆菌10d疗效。方法分析经14C尿素呼气实验及胃黏膜病理检查(Warthin-Stary染色阳性)证实有Hp感染患者198例资料。随机分两组,试验组115例患者口服阿莫西林双氯西林钠胶囊1.125,埃索美拉唑镁肠溶片20mg,克拉霉素片500mg,对照组83例患者口服阿莫西林1.0,埃索美拉唑镁肠溶片20mg,克拉霉素片500mg,三联药物均为每日两次,总疗程10d。所有患者停药四周以上行14C尿素呼气实验及胃黏膜病理检查检测HP根除率。结果 198例患者均完成10天治疗疗程及1月复查HP。两组Hp根除率分别为94.78%和73.49%(P<0.05),二者不良反应发生率分别为3.48%和3.6%(P>0.05),未发现严重的不良反应,所有患者均能耐受。试验组与对照组Hp根除率有显著性差异(P<0.05)。结论试验组根除Hp疗效显著优于对照组(P<0.05)。
Objective To compare the triple therapy amoxicillin dicloxacillin sodium capsules, esomeprazole magnesium enteric-coated tablets, clarithromycin tablets and amoxicillin sodium capsules, esomeprazole magnesium enteric-coated tablets, clarithromycin tablet pyloric eradication Helicobacter 10d efficacy. Methods The data of 198 cases of Hp infection confirmed by 14C urea breath test and gastric mucosal pathological examination (Warthin-Stary staining positive) were analyzed. Randomly divided into two groups, 115 patients in the experimental group oral amoxicillin diclofenac sodium capsules 1.125, esomeprazole magnesium enteric-coated tablets 20mg, clarithromycin tablets 500mg, 83 patients in the control group oral amoxicillin 1.0 A Somolazole magnesium enteric-coated tablets 20mg, clarithromycin tablets 500mg, triple drugs are twice daily for a total course of 10d. All patients discontinued more than four weeks 14C urea breath test and gastric mucosal pathology to detect HP eradication rate. Results 198 patients completed 10 days of treatment and January review of HP. The eradication rates of Hp in both groups were 94.78% and 73.49%, respectively (P <0.05). The adverse reactions were 3.48% and 3.6% respectively (P> 0.05). No serious adverse reactions were found and all patients were able to tolerate . Hp eradication rates in the experimental and control groups were significantly different (P <0.05). Conclusion The efficacy of eradication of Hp in experimental group was significantly better than that in control group (P <0.05).