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目的 探讨癌胚抗原 (CEA)和腺苷脱氨酶 (ADA )的检测对良性 (结核 )与恶性胸腔积液的鉴别价值。方法 分别采用ELISA和氨试剂法对 134例胸腔积液患者的CEA、ADA进行检测分析。结果 结核性胸腔积液和恶性胸腔积液患者CEA阳性检出率分别为 1.2 % (1/ 86 )和 6 8.8% (33/ 4 8) ,特异性为 98.8% (P <0 .0 1)。结核性胸腔积液和恶性胸腔积液患者ADA活性分别为 (41.5± 2 5 .7)U /L和 (9.6± 7.7)U /L ,前者是后者的 4倍 (P <0 .0 1)。结论 胸腔积液CEA及ADA的检测对结核与恶性胸腔积液有鉴别诊断价值。
Objective To investigate the diagnostic value of carcinoembryonic antigen (CEA) and adenosine deaminase (ADA) in benign (tuberculosis) and malignant pleural effusion. Methods The CEA and ADA in 134 cases of pleural effusion were detected by ELISA and ammonia reagent respectively. Results The positive rates of CEA in patients with tuberculous pleural effusion and malignant pleural effusion were 1.2% (1/86) and 68.8% (33/48), respectively, and the specificity was 98.8% (P0.01) . ADA activity in patients with tuberculous pleural effusion and malignant pleural effusion were (41.5 ± 2.57) U / L and (9.6 ± 7.7) U / L, respectively, the former being four times higher than the latter (P <0.01 ). Conclusions The detection of CEA and ADA in pleural effusion has differential diagnostic value for tuberculosis and malignant pleural effusion.