利用激光光解结合稳态吸收光谱技术,对放线菌素D的模型化合物ADE与DNA和牛血清蛋白的相互作用进行了系统研究。结果发现,ADE与ssDNA、dsDNA以及BSA都能发生非共价结合,并能发生光诱导的电子转移反应。结果表明,放线菌素类化合物有可能被用作I型的光敏治疗药物,并将为这类化合物的结构改造提供一些有益的启示。 The interaction between actinomycin D model compound ADE and DNA and bovine serum albumin was systematically studied by using laser photolysis coupled with steady state absorption spectroscopy. The results showed that ADE and ssDNA, dsDNA and BSA can occur non-covalent binding, and can occur light-induced electron transfer reaction. The results show that actinomycin compounds may be used as type I photosensitizers and will provide some beneficial implications for the structural transformation of these compounds.