Two Inter-cell Interference (ICI) management algorithms: Primary Interference Balancing (PIB) algorithm and Interfering Bits Loading A-voidance (IBLA) algorithm are proposed for canceling the ICI effects which the existing efficient radio resource allocation algorithms do not consider. The efficient radio resource allocation algorithm, i. e., Pre-assignment and Reassignment (PR) algorithm, obtains the lowest complexity and achieves good throughput performance in single cell OFDMA system. However, in multi-cell multi-sector OFDMA networks, PR algorithm is not applicable because it does not take ICI into consideration. The proposed PIB algorithm balances the number of loading bits for the desired User Equipment (UE) and the major interfering UE, as well as optimizes the SINR performance; meanwhile, IBLA a-voids loading certain number of interfering bits which would make SINR unqualified. Simulations confirm the ICI management effectiveness and feasibility of both the proposals.