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目的观察卡托普利联用小剂量螺内酯(安体舒通)对老年肺心病心力衰竭的疗效。方法入选61例符合标准的病例,随机分为31例治疗组和对照组30例。其中31例治疗组在接受常规治疗的同时,加用卡托普利联用小剂量螺内酯(安体舒通),根据心衰纠正情况观察,比较两组疗效。结果应用卡托普利联用小剂量螺内酯(安体舒通)有效率达90.3%,对照组有效率为73.3%。两组比较有差异有统计学意义(P<0.05)。结论卡托普利联用小剂量螺内酯可最大程度拮抗醛固酮作用,对抗因应用转化酶抑制剂而造成的醛固酮逃逸,且副作用小,可做为肺心病心力衰竭常规用药,临床疗效较肯定。
Objective To observe the curative effect of Captopril combined with low dose spironolactone (spironolactone) on heart failure in elderly patients with pulmonary heart disease. Methods Selected 61 cases of standard cases, were randomly divided into 31 cases of treatment group and control group of 30 cases. 31 patients in the treatment group received routine treatment, plus captopril combined with a small dose of spironolactone (spironolactone), according to the correction of heart failure observed, the two groups were compared. Results Captopril combined with low-dose spironolactone (spironolactone) effective rate of 90.3%, the control group was 73.3%. The difference between the two groups was statistically significant (P <0.05). Conclusions Captopril combined with low-dose spironolactone can antagonize the effect of aldosterone to a maximum extent, resist the aldosterone escape caused by the use of invertase inhibitors and have low side effects and can be used as a regular medication for heart failure due to cor pulmonale. The clinical efficacy is relatively positive.