在肝微粒体的脂质过氧化作用有两种:一种是酶促反应,即NADPH-P_(450)还原酶和细胞色素P_(450)等,另一种是非酶促反应。实验动物由ADP-NADPH或ADP-Fe~(3+)诱导的属酶促反应,由维生素C-Fe~(2+)诱导的属非酶促反应。日本东北大学药物研究所的一份研究报告指出:甘草次酸抑制ADP-Fe~(3+)或维生素C-Fe~(2+)诱导脂质过氧化,其抑制强度低于维生素E,也抑制CCl_4诱导肝微粒体脂质过氧化,其 There are two types of lipid peroxidation in liver microsome: one is enzymatic reaction, NADPH-P 450 reductase and cytochrome P 450, and the other is non-enzymatic reaction. The experimental animals are enzymatically induced by ADP-NADPH or ADP-Fe 3+ and are non-enzymatic reactions induced by vitamin C-Fe 2+. A report from the Institute of Materia Medica, Tohoku University pointed out that glycyrrhetinic acid inhibits lipid peroxidation induced by ADP-Fe ~ (3+) or vitamin C-Fe ~ (2+) and its inhibitory strength is lower than that of vitamin E Inhibit CCl_4-induced liver microsomal lipid peroxidation