Dear Editor,Macroautophagy (referred to as autophagy herein) is an evolutionarily conserved,lysosomal degradation process by which cells rid themselves of aggregated proteins and damaged organelles (He and Klionsky,2009).This process involves a finely orchestrated molecular pathway comprising a plethora of ATG proteins essential for autophagosome formation.The mammalian Unc-51-like kinase (ULK) complex plays an essential role to initiate canonical autophagy pathway by relaying upstream nutrient and stress signals to downstream autophagy machinery (Mizushima,2010;Wong et al.,2013).